Highly potent synthetic opioids known as nitazenes are being linked to a growing number of deaths across the UK, with 286 inquests connected to the drugs by March 2025. Experts warn they can be many times stronger than heroin and are often mixed into other substances without users’ knowledge. In many cases, people believe they are taking prescription painkillers or heroin, only to ingest a far more dangerous substitute. Gus, aged 21, died after unknowingly taking a tablet sold as oxycodone which contained a nitazene. His mother Nicola said she had never heard of the drug before reading his post-mortem report. Most recorded deaths were accidental, predominantly involving men, and often linked to polydrug use. Vulnerable groups, including those with unstable housing or mental health conditions, are disproportionately affected. Authorities believe nitazenes are being smuggled in small quantities by post and mixed for profit. Campaigners are urging wider access to naloxone, the overdose-reversing antidote, and improved detection systems to prevent further tragedy.